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Important measures in vitamin D mediated transcriptional regulation include 1) binding of vitamin D on its cognate vitamin D receptor (VDR), 2) the translocation of vitamin D receptor (VDR)-retinoid X receptor heterodimer intricate in the nucleus, 3) binding VDR-RXR complicated on the TRPV6 gene promoter, 4) recruitment of steroid receptor coactivator one and RNA polymerase II on the promoter, and 5) transcriptional activation mediated via histone H4 acetylation functions. Calcium influx from the diet regime and its subsequent binding to calbindin-D9k could be the rate-limiting stage that modulates vitamin D-dependent regulation TRPV6. At minimum 5 vitamin D response aspects (VDREs) at positions −1.2, −2.1, −3.5, −4.3, and −5.5 kb relative to transcriptional start out web site (TSS) have been determined on TRPV6 transcripts. Among these 5 internet sites, VDREs at positions −1.2, −2.1, Fanvoz.com and −4.3 kb are appreciably much more responsive to 1,25-(OH)2D3 in comparison to VDREs positioned at −3.5 and −5.5 kb which do not surface to contribute significantly to vitamin D mediated transcriptional regulation in the intestine. Estrogen, progesterone, and dexamethasone are acknowledged to upregulate TRPV6 expression in the cerebral cortex and hypothalamus of mice suggesting a likely involvement of TRPV6 in calcium absorption in the mind

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