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Research has noted that the interaction between BDNF and TrkB (the receptor to BDNF) is really critical in inducing dendritic growth some have pointed out that the phosphorylation of TrkB by another molecule, cdk5 is required for this interaction to manifest. Animals chronically exposed to prescription drugs of abuse show enhanced ranges of BDNF in the ventral tegmental space (VTA) of the mind, and when BDNF is injected right into the VTA of rats, the animals act as if they are addicted to and psychologically dependent upon opiates. BDNF concentrations show up to be hugely controlled all over the life time both equally in the early developmental stages and in the later stages of existence. Ernfors P, Kucera J, Lee KF, Loring J, Jaenisch R (October 1995). "Studies on the physiological position of brain-derived neurotrophic issue and neurotrophin-3 in knockout mice". Dincheva I, Lynch NB, Lee FS (October 2016). "The Role of BDNF in the Development of Fear Learning". Notaras M, van den Buuse M (October 2020). "Neurobiology of BDNF in worry memory, sensitivity to anxiety, and anxiety-relevant problems". Vargas-Perez H, Ting-A Kee R, Walton CH, Hansen DM, Razavi R, Clarke L, Bufalino MR, Allison DW, Steffensen SC, van der Kooy D (June 2009). "Ventral tegmental location BDNF induces an opiate-dependent-like reward state in naive rats"