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10.3233/JAD-2010-1400. PMC 9361505. PMID 20182056. By focusing on A1-A2A receptor heteromers in striatal glutamatergic terminals and A1 receptors in striatal dopaminergic terminals (presynaptic brake), caffeine induces glutamate-dependent and glutamate-impartial launch of dopamine. These presynaptic results of caffeine are potentiated by the release of the postsynaptic brake imposed by antagonistic interactions in the striatal A2A-D2 and A1-D1 receptor heteromers. Paul L. "Why Caffeine is Toxic to Birds". International Journal of Epidemiology. American Journal of Epidemiology. The Journal of Nutrition, Health & Aging. Journal of Neurology, Neurosurgery and Psychiatry, eighty four (10), 1092 - 1099 . The Journal of Allergy and Clinical Immunology. The Australian and New Zealand Journal of Psychiatry. Psychiatry. Vol. one. New York: John Wiley & Sons. When prosecutions were being instituted, substantial numbers emigrated to Roumania and there took the title of "Lipovans." Women, specifically 1 of the name of Anna Romanovna, have had a good share in the invention and diffusion of the doctrine

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PMC 3898681. PMID 24459410. Despite THE Importance OF Numerous PSYCHOSOCIAL Factors, AT ITS Core, DRUG Addiction Involves A Biological Process: the capacity of repeated exposure to a drug of abuse to induce variations in a vulnerable mind that generate the compulsive trying to get and getting of drugs, and loss of control about drug use, that determine a state of dependancy. Principles of addiction in depth addictive behaviors and diseases (1st ed.). In Spiller GA (ed.). Benjamin LT, Rogers AM, Rosenbaum A (January 1991). "Coca-Cola, caffeine, and psychological deficiency: Harry Hollingworth and the Chattanooga trial of 1911". Journal of the History of the Behavioral Sciences. Smit HJ, Gaffan EA, Rogers PJ (November 2004). "Methylxanthines are the psycho-pharmacologically lively constituents of chocolate". Brown DW (2004). A new introduction to Islam. Amazon's review program permits peer-to-peer reserve ratings. PMC 2699625. PMID 19428492. Through these interactions, caffeine is ready to instantly potentiate dopamine neurotransmission, therefore modulating the rewarding and addicting attributes of anxious program stimuli

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